Publicaciones

Identification of a novel mechanism for LFA‐1 organization during NK cytolytic response Pariani AP, Almada E, Hidalgo F, Borini-Etichetti C, Vena C, Marín C, Favre C, Goldenring JR, Larocca MC. J. Cell. Physiol. 2022;. doi: 10.1002/jcp.30921.

The chemoprotective effects of IFN-α-2b on rat hepatocarcinogenesis are blocked by vitamin E supplementation Vera MC, Lucci A, Ferretti AC, Abbondanzieri AA, Comanzo CG, Lorenzetti F, Pisani GB, Ceballos MP, Alvarez ML, Carillo MC, Quiroga AD. . J Nutr Biochem . 2021;18;96:108806.. doi: 10.1016/j.jnutbio.2021.108806..

Protective effect of genistein pre-treatment on paraquat hepatotoxicity in rats. Semeniuk M, Ceré LI, Ciriaci N, Bucci-Muñoz M, Quiroga AD, Luquita MG, Roma S, Catania VA, Mottino AD, Rigalli JP, Ruiz ML. Toxicol Appl Pharmacol. 2021;426:115636. doi: 10.1016/j.taap.2021.115636.

Sirtuin 1 and 2 inhibitors enhance the inhibitory effect of sorafenib in hepatocellular carcinoma cells. Ceballos MP, Angel A, Delprato BC, Livore VI, Ferretti AC, Lucci A, Comanzo CG, Alvarez ML, Quiroga AD, Mottino AD, Carillo MC. . Eur J Pharmacol . 2021. ;892:173736.. doi: 10.1016/j.ejphar.2020.173736. .

Further evidence for the involvement of mitochondrial aquaporin-8 in hepatocyte lipid synthesis Danielli M, Capiglioni AM, Marrone J, Marinelli RA . Biochimie . 2021;(en prensa). doi: 10.1016/j.biochi.2021.01.008.

Enhanced ammonia detoxification to urea in hepatocytes transduced with human aquaporin-8 gene Capiglioni AM, Muller GL, Marrone J, Alvarez ML, Marinelli RA . Biotechnology and Bioengineering . 2021 ;(en prensa). doi: 10.1002/bit.27901 .

Acute regulation of apical ABC transporters in the gut. Potential influence on drug bioavailability Domínguez CJ, Tocchetti GN, Rigalli JP, Mottino AD. Pharmacol Res. 2021;163:105251. doi: 10.1016/j.phrs.2020.105251.

Induction of P-glycoprotein expression and activity by prolactin in female rat liver Ceré LI, Sedlmeier MG, Semeniuk M, Luquita ML, Rigalli JP, Francés D, Ronco MT, Ruiz ML and Catania VA. . Life Sci. 2021;119936. doi: 10.1016/j.lfs.2021.119936.

Multidrug resistance-associated protein 2 is negatively regulated by oxidative stress in rat intestine via a posttranslational mechanism. Impact on its membrane barrier function Zecchinati F, Barranco MM, Tocchetti GN, Domínguez CJ, Arana MR, Perdomo VG, Mottino AD, García F, Villanueva SSM. Toxicology. 2021;460:152873. doi: 10.1016/j.tox.2021.152873.

Oxidative stress and localization status of hepatocellular transporters: Impact on bile secretion and role of signaling pathways Basiglio CL, Crocenzi FA, Sánchez Pozzi EJ, Roma MG. Antioxid Redox Signal. 2021;. doi: 10.1089/ars.2021.0021.

IFN-α-2b induces apoptosis by decreasing cellular cholesterol levels in rat preneoplastic hepatocytes. Quiroga AD, Vera MC, Ferretti AC, Lucci A, Comanzo CG, Lambertucci F, Ceballos MP, Carrillo MC. . Cytokine. 2020;133: 155172. . doi: 10.1016/j.cyto.2020.155172. .

Hepatic glycerol metabolism is early reprogrammed in rat liver cancer development. Lorenzetti F, Capiglioni AM, Marinelli RA, Carrillo MC, Alvarez ML. . Biochimie . 2020;170:88-93.. doi: 10.1016/j.biochi.2020.01.002.

Intraluminal nutrients acutely strengthen rat intestinal MRP2 barrier function by a glucagon-like peptide-2-mediated mechanism. Tocchetti GN, Domínguez CJ, Zecchinati F, Arana MR, Rigalli JP, Ruiz ML, Villanueva SSM, Mottino AD. Acta Physiol (Oxf). 2020 ;1:e13514. doi: 10.1111/apha.13514.

Regulation of hepatic P-gp expression and activity by genistein in rats Semeniuk M, Ceré LI, Ciriaci N, Bucci-Muñoz M, Villanueva SSM, Mottino AD, Catania VA, Rigalli JP, Ruiz ML. Arch Toxicol. 2020;94(5):1625-1635. doi: 10.1007/s00204-020-02708-3.

Role of interleukin 1 beta in the regulation of rat intestinal multidrug resistance-associated protein 2 under conditions of experimental endotoxemia Arana MR, Dominguez CJ, Zecchinati F, Tocchetti GN, Mottino AD, Villanueva SSM. Toxicology. 2020;441:152527. doi: 10.1016/j.tox.2020.152527.

AKAP350 enables p150glued /EB1 interaction at the spindle poles Almada E, Pariani A, Rivabella Maknis T, Hidalgo F, Vena R, Favre C, Larocca MC. Biochimie. 2020;177:127-131. doi: 10.1016/j.biochi.2020.08.014.

Identification of a CIP4 PKA phosphorylation site involved in the regulation of cancer cell invasiveness and metastasis Tonucci FM, Almada E, Borini-Etichetti C, Pariani A, Hidalgo F, Rico MJ, Girardini J, Favre C, Goldenring JR, Menacho-Marquez M, Larocca MC. Cancer Lett. 2019;461:65-77. doi: 10.1016/j.canlet.2019.07.006.

Metformin and glucose starvation decrease the migratory ability of hepatocellular carcinoma cells: targeting AMPK activation to control migration. Ferretti AC, Hidalgo F, Tonucci FM, Almada E, Pariani A, Larocca MC, Favre C.. Sci Rep . 2019;9, 2815. doi: oi.org/10.1038/s41598-019-39556-w.

Participation of 5-lipoxygenase and LTB4 in liver regeneration after partial hepatectomy. Lorenzetti F, Vera MC, Ceballos MP, Ronco MT, Pisani GB, Monti JA, Lucci A, Comanzo CG, Tordjmann T, Carrillo MC, Quiroga AD, Alvarez ML. . Sci Rep . 2019.;9: 18176. . doi: 10.1038/s41598-019-54652-7..

IFN-α-2b treatment protects against diet-induced obesity and alleviates non-alcoholic fatty liver disease in mice. Quiroga AD, Comanzo CG, Heit Barbini FJ, Lucci A, Vera MC, Lorenzetti F, Ferretti AC, Ceballos MP, Alvarez ML, Carrillo MC. . Toxicol Appl Pharmacol . 2019.;379:114650.. doi: 10.1016/j.taap.2019.114650. .

Vitamin K2 supplementation blocks the beneficial effects of IFN-α-2b administered in the early stages of liver cancer development in rats. Vera MC, Lorenzetti F, Lucci A, Comanzo CG, Ceballos MP, Pisani GB, Alvarez ML, Quiroga AD, Carrillo MC. . Nutrition . 2019;59: 170-179.. doi: 10.1016/j.nut.2018.08.016..

Mitochondrial aquaporin-8 is involved in SREBP-controlled hepatocyte cholesterol biosynthesis Danielli M, Marrone J, Capiglioni AM, Marinelli RA. Free Radic. Biol. Med. 2019;131: 370-375, . doi: 10.1016/j.freeradbiomed.2018.12.016.

ABC Transporters: From Basic Knowledge to Potential Clinical Application Mottino A. Curr Med Chem. 2019;26(7): 1060-1061. doi: 10.2174/092986732607190514073051.

ABC Transporters: Regulation and Association with Multidrug Resistance in Hepatocellular Carcinoma and Colorectal Carcinoma Ceballos MP, Rigalli JP, Ceré LI, Semeniuk M, Catania VA, Ruiz ML. Curr Med Chem. 2019;26(7):1224-1250. doi: 10.2174/0929867325666180105103637.

Reversion of down-regulation of intestinal multidrug resistance-associated protein 2 in fructose-fed rats by geraniol and vitamin C: Potential role of inflammatory response and oxidative stress Zecchinati F, Barranco MM, Arana MR, Tocchetti GN, Domínguez CJ, Perdomo VG, Ruiz ML, Mottino AD, García F, Villanueva SSM.. J Nutr Biochem. 2019;68:7. doi: 10.1016/j.jnutbio.2019.03.002.

Role of ERK1/2 in TNFα-induced internalization of Abcc2 in rat hepatocyte couplets Ciriaci N, Andermatten RB, Razori MV, Schuck VS, Miszczuk GS, Medeot CS, Crocenzi FA, Roma MG, Barosso IR, Ruiz ML, Sánchez Pozzi EJ. Biochem Pharmacol. 2019;164 :311-320. doi: 10.1016/j.bcp.2019.04.024.

Sphingosine 1-phosphate receptor 2/adenylyl cyclase/protein kinase A pathway is involved in taurolithocholate-induced internalization of Abcc2 in rats. Andermatten RB, Ciriaci N, Schuck VS, Di Siervi N, Razori MV, Miszczuk GS, Medeot AC, Davio CA, Crocenzi FA, Roma MG, Barosso IR, Sánchez Pozzi EJ. Arch Toxicol.. 2019; 93(8):2279-2294. doi: 10.1007/s00204-019-02514-6.

Heme oxygenase-1 induction by hemin prevents oxidative stress-induced acute cholestasis in the rat Martín PL, Ceccatto P, Razori MV, Francés DEA, Arriaga SMM, Pisani GB, Martínez AI, Sánchez Pozzi EJ, Roma MG, Basiglio CL.. Clin Sci (Lond). 2019;133(1):117-134. doi: 10.1042/CS20180675.

Anticholestatic mechanisms of ursodeoxycholic acid in lipopolysaccharide-induced cholestasis Razori MV, Maidagan PM, Ciriaci N, Andermatten RB, Barosso IR, Martín PL, Basiglio CL, Sánchez Pozzi EJ, Ruiz ML, Roma MG. Biochem Pharmacol. 2019;168:48-56. doi: 10.1016/j.bcp.2019.06.009.

Microtubules regulate brush border formation Tonucci FM, Ferretti A, Almada E, Cribb P, Vena R, Hidalgo F, Favre C, Tyska MJ, Kaverina I, Larocca MC. J Cell Physiol. 2018;233:1468-1480. doi: 10.1002/jcp.26033.

Inhibition of sirtuins 1 and 2 impairs cell survival and migration and modulates the expression of P-glycoprotein and MRP3 in hepatocellular carcinoma cell lines. Ceballos MP, Decándido G, Quiroga AD, Comanzo CG, Livore VI, Lorenzetti F, Lambertucci F, Chazarreta-Cifre L, Banchio C, Alvarez ML, Mottino AD, Carrillo MC. 2018. . Toxicol Lett . 2018;289:63-74.. doi: 10.1016/j.toxlet.2018.03.011..

Attenuation of liver cancer development by oral glycerol supplementation in the rat. Capiglioni AM, Lorenzetti F, Quiroga AD, Parody JP, Ronco MT, Pisani GB, Carrillo MC, Ceballos MP, Alvarez ML. . Eur J Nutr.. 2018;57(3):1215-1224. . doi: 10.1007/s00394-017-1404-4. .

Inhibition of multidrug resistance-associated protein 2 (MRP2) activity by the contraceptive nomegestrol acetate in HepG2 and Caco-2 cells. Tocchetti GN, Domínguez CJ, Zecchinati F, Arana MR, Ruiz ML, Villanueva SSM, Mottino AD, Weiss J, Rigalli JP. Eur J Pharm Sci. 2018;122: 205-213. doi: 10.1016/j.ejps.2018.07.017.

Activation of Insulin-like growth factor 1 receptor participates downstream of GPR30 in estradiol-17ß-D-glucuronide induced cholestasis in rats Barosso IR, Miszczuk GS, Ciriaci N, Andermatten RB, Maidagan PM, Razori V, Taborda DR, Roma MG, Crocenzi FA, Sánchez Pozzi EJ. Arch Toxicol. 2018; 292:729-744. doi: 10.1007/s00204-017-2098-3.

Mechanisms of canalicular transporter endocytosis in the cholestatic rat liver Miszczuk G.S., Barosso I.R., Larocca M.C., Marrone J., Marinelli R.A., Boaglio A.C., Sánchez Pozzi E.J., Roma M.G., Crocenzi F.A. Biochim Biophys Acta. 2018;1864(4 Pt A):1072-1085. doi: 10.1016/j.bbadis.2018.01.015.

Akap350 Recruits Eb1 to The Spindle Poles, Ensuring Proper Spindle Orientation and Lumen Formation in 3d Epithelial Cell Cultures Almada E, Tonucci FM, Hidalgo F, Ferretti A, Ibarra S, Pariani A, Vena R, Favre C, Girardini J, Kierbel A, Larocca MC. Sci Rep. 2017;7:14894. doi: 10.1038/s41598-017-14241-y.

Intestinal multidrug resistance-associated protein 2 is down-regulated in fructose-fed rats Londero AS, Arana MR, Perdomo VG, Tocchetti GN, Zecchinati F, Ghanem CI, Ruiz ML, Rigalli JP, Mottino AD, García F, Villanueva SSM. J Nutr Biochem. 2017;40:178-186. doi: 10.1016/j.jnutbio.2016.11.002.

AMPK and PKA interaction in the regulation of survival of liver cancer cells subjected to glucose starvation. Ferretti AC, Tonucci FM, Hidalgo F, Almada E, Larocca MC, Favre C.. Oncotarget . 2016;7(14), 17815-17828. doi: doi:10.18632/oncotarget.7404.

Hepatic carboxylesterase 3 (Ces3/Tgh) is downregulated in the early stages of liver cancer development in the rat. Quiroga AD, Ceballos MP, Parody JP, Comanzo CG, Lorenzetti F, Pisani GB, Ronco MT, Alvarez ML, Carrillo MC. . Biochim Biophys Acta (BBA) - Mol Basis Dis . 2016. ;1862(11):2043-2053. . doi: 10.1016/j.bbadis.2016.08.006..

Hepatic Gene Transfer of Human Aquaporin-1 improves bile salt secretory failure in rats with estrogen-induced cholestasis Marrone J, Soria LR, Danielli M, Lehmann GL, Larocca MC, Marinelli RA. Hepatology . 2016 ;64:535-548. doi: 10.1002/hep.28564.

The trypanocidal benznidazole promotes adaptive response to oxidative injury: Involvement of the nuclear factor-erythroid 2-related factor-2 (Nrf2) and multidrug resistance associated protein 2 (MRP2) Rigalli JP, Perdomo VG, Ciriaci N, Francés D, Ronco MT, Bataille AM, Ghanem CI, Ruiz ML, Manautou JE and Catania VA. Toxicol Appl Pharmacol. 2016;304:90-98. doi: 10.1016/j.taap.2016.05.007.

Up-regulation of ATP-binding cassette transporters in the THP-1 human macrophage cell line by the antichagasic benznidazole Perdomo VG, Rigalli JP, Luquita MG, Pellegrino JM, Ruiz ML and Catania VA. Mem. Inst. Oswaldo Cruz. 2016;111: 707-711. doi: 10.1590/0074-0276016008.

Modulation of Expression and Activity of ABC Transporters by the Phytoestrogen Genistein. Impact on Drug Disposition Rigalli JP, Ciriaci N, Mottino AD, Catania VA, Ruiz ML. Curr Med Chem. 2016;23(13):1370-89. doi: 10.2174/0929867323666160406120711.

Physiological and pathophysiological factors affecting the expression and activity of the drug transporter MRP2 in intestine. Impact on its function as membrane barrier Arana MR, Tocchetti GN, Rigalli JP, Mottino AD, Villanueva SS. Pharmacol Res. 2016;109:32-44. doi: 10.1016/j.phrs.2016.04.014.

EGFR participates downstream of ERα in estradiol-17ß-D-glucuronide induced impairment of Abcc2 function in isolated rat hepatocyte couplets Barosso IR, Zucchetti AE, Miszczuk GS, Boaglio AC, Taborda DR, Roma MG, Crocenzi FA y Sánchez Pozzi EJ. Archives of Toxicology. 2016;90 (4) 891-903. doi: 10.1007/s00204-015-1507-8.

Centrosomal AKAP350 and CIP4 act in concert to define the polarized localization of the centrosome and Golgi in migratory cells Tonucci FM, Hidalgo F, Ferretti A, Almada E, Favre C, Goldenring JR, Kaverina I, Kierbel A, Larocca MC. J Cell Sci. 2015;128:3277-89. doi: 10.1242/jcs.170878.

Regulation of multidrug resistance proteins by genistein in a hepatocarcinoma cell line: impact on sorafenib cytotoxicity Rigalli JP, Ciriaci N, Arias A, Ceballos MP, Villanueva SS, Luquita MG, Mottino AD, Ghanem CI, Catania VA, Ruiz ML. PLoS One. 2015;10(3):e0119502. doi: 10.1371/journal.pone.0119502.

Adenoviral transfer of human aquaporin-1 gene to rat liver improves bile flow in estrogen-induced cholestasis Marrone J, Lehmann GL, Soria LR, Pellegrini JM, Molinas SM, Marinelli RA . Gene Therapy . 2014;21:1058-64. doi: 10.1038/gt.2014.78.

G protein-coupled receptor30–adenylyl cyclase–protein kinase A pathway is involved in estradiol 17ß-D-glucuronide-induced cholestasis Zucchetti AE, Barosso IR, Boaglio AC, Basiglio CL, Taborda DR, Luquita MG, Davio CA, Roma MG, Crocenzi FA, Sánchez Pozzi EJ. Hepatology. 2014;59 (3) 1016-1029. doi: 10.1002/hep.26752.

Physiological concentrations of unconjugated bilirubin prevent oxidative stress-induced hepatocanalicular dysfunction and cholestasis Basiglio CL, Toledo FD, Boaglio AC, Arriaga SM, Ochoa JE, Sánchez Pozzi EJ, Mottino AD, Roma MG. Arch Toxicol. 2014;88(2):501-14. doi: 10.1007/s00204-013-1143-0.

Ammonia detoxification via ureagenesis in rat hepatocytes involves mitochondrial aquaporin-8 channels. Soria LR, Marrone J, Calamita G, Marinelli RA. Hepatology . 2013; 57:2061-71. doi: 10.1002/hep.26236.

Hormonal modulation of hepatic cAMP prevents estradiol 17ß-D-glucuronide induced cholestasis in perfused rat liver Zucchetti AE, Boaglio AC, Barosso IR, Luquita MG, Roma MG, Crocenzi FA, Sánchez Pozzi EJ. Digest Dis Sci . 2013;58 (6): 1602-1614. doi: 10.1007/s10620-013-2558-4.

Modulation of biotransformation systems and ABC transporters by benznidazole in rats Perdomo VG, Rigalli JP, Villanueva SS, Ruiz ML, Luquita MG, Echenique CG, Catania VA. Antimicrob Agents Chemother. 2013;57(10):4894-902. doi: 10.1128/AAC.02531-12.

Protein kinase A signals apoptotic activation in glucose-deprived hepatocytes: participation of reactive oxygen species. Ferretti AC, Mattaloni SM, Ochoa JE, Larocca MC, Favre C. . Apoptosis . 2012;17, 475–491. doi: doi.org/10.1007/s10495-012-0697-2.

Nutritional stress in eukaryotic cells: oxidative species and regulation of survival in time of scarceness. Ferretti AC, Larocca MC, Favre C. . Mol Genet Metab . 2012;105(2),186-92 . doi: doi:10.1016/j.ymgme.2011.11.007.

Sequential activation of classic PKC and estrogen receptor α is involved in estradiol 17ß-D-glucuronide-induced cholestasis Barosso I, Zucchetti A, Boaglio A, Taborda D, Roma M, Crocenzi F, Sánchez Pozzi E. Plos One . 2012;. doi: 10.1371/journal.pone.0050711.

ERK1/2 and p38 MAPKs are complementarily involved in estradiol 17ß-D-glucuronide-induced cholestasis: crosstalk with cPKC and PI3K Boaglio A.C., Zucchetti A.E., Toledo F.D., Barosso I.R., Sánchez Pozzi E.J., Crocenzi F.A.*, Roma M.G*. *Autoría de correspondencia compartida. PLoS ONE . 2012;7(11): e49255. doi: 10.1371/journal.pone.0049255.

Prevention of estradiol 17β-D-glucuronide-induced canalicular transporter internalization by hormonal modulation of cAMP in rat hepatocytes Zucchetti A, Barosso I, Boaglio A, Pellegrino J, Ochoa J, Roma M, Crocenzi F, Sánchez Pozzi E. Mol Biol Cell . 2011;22: 3902-3915. doi: 10.1091/mbc.E11-01-0047.

Induction of intestinal multidrug resistance-associated protein 2 by glucagon-like peptide-2 in the rat. Villanueva SS, Arias A, Ruiz ML, Rigalli JP, Pellegrino JM, Vore M, Catania VA, Mottino AD. J Pharmacol Exp Ther. 2010;335: 332-341. doi: .

Phosphoinositide 3-kinase/protein kinase B signaling pathway is involved in estradiol 17β-D-glucuronide-induced cholestasis: complementarity with classical protein kinase C Boaglio A.C., Zucchetti A.E., Sánchez Pozzi E.J., Pellegrino J.M., Ochoa J.E., Mottino A.D., Vore M, Crocenzi F.A., Roma M.G. Hepatology. 2010;52(4):1465-1476. doi: 10.1002/hep.23846.

Ca2+-dependent protein kinase C isoforms are critical to estradiol 17ß-D-glucuronide-induced cholestasis in the rat Crocenzi F.A., Sánchez Pozzi E.J., Ruiz M.L., Zucchetti A.E., Roma M.G., Mottino A.D. and Vore M. Hepatology. 2008;48(6):1885-1895. doi: 10.1002/hep.22532.

Protective role of unconjugated bilirubin on complement-mediated hepatocytolysis Basiglio CL, Arriaga SM, Pelusa HF, Almará AM, Roma MG, Mottino AD.. Biochim Biophys Acta. 2007;1770(7):1003-10. doi: 10.1016/j.bbagen.2007.03.005.

Estradiol-17β-D-glucuronide induces endocytic internalization of Bsep in rats. Crocenzi F.A., Mottino A.D., Cao J, Veggi L.M., Sánchez Pozzi E.J., Vore M, Coleman R, Roma MG. Am. J. Physiol. Gastrointest. and Liver Physiology . 2003;285(2): G449-G459. doi: 10.1152/ajpgi.00508.2002.

ABC Transporters: Regulation and Association with Multidrug Resistance in Hepatocellular Carcinoma and Colorectal Carcinoma Ceballos MP, Rigalli JP, Ceré LI, Semeniuk M, Catania VA, Ruiz ML. Curr Med Chem. ;26(7):1224-1250. doi: 10.2174/0929867325666180105103637.